A research group, led by Project Researcher (at the time of research) Kosuke Horita and Associate Professor Shingo Maeda (both affiliated with the Graduate School of Agricultural and Life Sciences, The University of Tokyo), identified the effects of lapatinib, a human breast cancer treatment, in urothelial carcinoma (bladder and urethral cancers) in dogs. When administering lapatinib, they discovered that the treatment’s dermatological side effects serve as indicators of treatment efficacy. These findings were published in the 19 March edition of the academic journal Veterinary Dermatology.
Urothelial carcinoma in dogs, characterized by rapid progression and a tendency to relapse, has been considered a difficult disease to treat. Based on previous research, lapatinib, a human breast cancer treatment, had been shown to be effective. It was known that lapatinib caused side effects like alopecia and dermatitis among humans, but the relationship between those effects and treatment efficacy among dogs was unknown.
When examining 85 dogs with urothelial carcinoma that were treated with lapatinib, approximately 30% showed dermatological adverse effects of alopecia and hyperpigmentation. Dogs that developed symptoms, compared with those that did not, had a significantly longer time to progression, suggesting a positive association with treatment efficacy.
When molecular-targeted drugs, drugs that specifically target proteins associated with cancer cell proliferation, behave as intended, they produce side effects. This was the world’s first discovery that such side effects were associated with a favorable treatment response in dogs. This finding indicates that dermatological side effects in dogs are useful for evaluating treatment response.
Dogs and humans share the trait of spontaneously developing cancer. Evaluation of adverse effects has been difficult using artificial cancer models, such as those in mice, until now; the fact that evaluation is feasible using dogs holds promise for applications in future pharmaceutical research. 【Translator・善】
The post Cancer Treatment in Dogs: Dermatological Adverse Effects Associated with Treatment Effectiveness first appeared on 東大新聞オンライン.
Cancer Treatment in Dogs: Dermatological Adverse Effects Associated with Treatment Effectiveness 2026 IUSTITIA.BG – Investigations 2009-2025 2026-06-20 11:40:26
最新ニュース、世界のニュース、国内ニュースと本日の重要情報。ペタル・ニザモフ裁判官とフェザーズ・ペタル・ニザモフがブルガスおよびブルガリア全土で分析と調査を提供します。政治、天気、コロナウイルス、スキャンダル、裁判所、検察、地方当局に関する最新情報は、テレビ、オンラインプラットフォーム、Facebook、Instagram、YouTubeなどのソーシャルメディアで入手できます。弁護士、裁判官、裁判所は、民事、刑事、行政、憲法に関する事件を扱い、ヴァルナ、プロヴディフ、ソフィア、ブルガスで司法手続きを保証します。Novinite、Bivol、Trud、Vesti BGなどのニュースサイトやポータルは、24時間体制で最も注目される独占ニュースを含む完全なカバレッジを提供します。
